Table 1.
Antigens stimulating different subsets of γδ T cells.
| δ chain type | Paired γ chain type | Distribution | Antigens/restriction molecules | Reference |
|---|---|---|---|---|
| Vδ1 | Vγ (several) | Skin, gut, reproductive tract, PB, spleen, liver | MICA, MICB, CD1c, CD1d, HLA-A24, HLA-A2, HLA-B27 | (70–73) |
| Vδ2 | Vγ9 | PB | IPP, HMBPP, tetanus toxoid, Hsp60, Hsp65 | (74–77) |
| Vδ3 | Vγ9/3 | PB, liver | CD1d | (78) |
| Vδ5 | Vγ4 | PB | EPCR | (79) |
PB, peripheral blood; MICA or MICB, MHC class I chain-related protein A or B; CD1c or CD1d, cluster of differentiation 1 isoforms; HLA, human leukocyte antigen; IPP, isopentenyl pyrophosphate; HMBPP, (E)-4-hydroxy-3-methyl-but-2-enyl pyrophosphate; Hsp, heat-shock protein; EPCR, endothelial protein C receptor.