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. 2017 Jun 22;8:1158. doi: 10.3389/fmicb.2017.01158

Figure 5.

Figure 5

BHI-Ft S4 appears more virulent than MHB-Ft S4 to mice immunized with MHB-LVS. Survival of C57BL/6 mice vaccinated three times with PBS or live MHB-Ft LVS prior to i.n. challenge with 26 ± 2 CFU of Ft S4 grown in MHB or BHI. Symbols are as defined in Figure 4; survival differences between immunized mice challenged with MHB-S4 and BHI-S4 are indicated by the stated p-values. Asterisks indicate significant differences between groups (PBS or LVS) that were identically-challenged; actual p valves are p < 0.0001 (MHB-S4) and p < 0.0001 (BHI-S4). All significant differences are indicated. MTS values are ≥ 21 d (LVS/MHB-S4), 13 d (LVS/BHI-S4), 8.3 d (PBS/MHB-S4), and 7.5 d (PBS/BHI-S4). The survival data from 40 mice (10 mice/group) are represented as Kaplan–Meier survival curves with statistical analysis by the Log-rank (Mantel–Cox) test.