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. 2017 Jun 22;8:1158. doi: 10.3389/fmicb.2017.01158

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Copyright © 2017 Holland, Rosa, Kristjansdottir, Wolfgeher, Franz, Zarrella, Kumar, Sunagar, Singh, Bakshi, Namjoshi, Barry, Sellati, Kron, Gosselin, Reed and Hazlett.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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BHI-Ft S4 appears more virulent than MHB-Ft S4 to mice immunized with BHI-LVS. Survival of C57BL/6 mice vaccinated twice with PBS or live BHI-Ft LVS prior to challenge with 29.5 ± 2.5 CFU of Ft S4 grown in MHB or BHI. Symbols are as defined in Fig 4; survival differences between immunized mice challenged with MHB-S4 and BHI-S4 are indicated by the stated p values. Asterisks indicate significant differences between groups (PBS or LVS) that were identically-challenged; actual p-values are p < 0.0001 (MHB-S4) and p < 0.017 (BHI-S4). All significant differences are indicated. MTS values are >21 d (LVS/MHB-S4), 13.8 d (LVS/BHI-S4), 6 d (PBS/MHB-S4), and 5.8 d (PBS/BHI-S4). The survival data from 46 mice (10–12 mice/group) are represented as Kaplan–Meier survival curves with statistical analysis by the Log-rank (Mantel–Cox) test.