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. 2017 Jun 22;8:295. doi: 10.3389/fneur.2017.00295

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Copyright © 2017 Blume, Beniaminov, Kämpe Björkvall, Machaczka and Svenningsson.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Main sequence of horizontal saccades. Upper: the main sequence illustrates the linear dependency of peak velocity and amplitude of a saccade. The main sequences of 20° horizontal saccades are shown for one Gaucher’s disease type 3 (GD3) patient (red) and one healthy control (HC) (blue). Lower: representative raw recordings of two exemplary horizontal saccades for the same GD3 patient (red, right) and HC (blue, left). The broken lines represent the appearance and disappearance of the 20° lateral stimulus. The GD3 saccades show longer duration, with decreased average velocity. Additionally, the gain of the first saccade is mildly reduced and one correction saccade is needed to reach the target.