Table 3. Performance of the HCV-MOSAIC risk score for a range of different cut-offs among HIV-infected men who have sex with men in the development and three validation studies.
| Development study | Validation studies | |||||||
|---|---|---|---|---|---|---|---|---|
| MOSAIC study, the Netherlands | Case–control study, Belgium | Case–control study, UK | Dutch STI clinic surveys | |||||
| Cut‑offa | Sensitivity (%) | Specificity (%) | Sensitivity (%) | Specificity (%) | Sensitivity (%) | Specificity (%) | Sensitivity (%) | Specificity (%) |
| ≥ 0.9 | 91.5 | 38.2 | 92.3 | 40.0 | 96.7 | 28.5 | 100.0 | 25.2 |
| ≥ 1.1 | 89.0 | 45.8 | 88.5 | 44.4 | 95.0 | 35.4 | 100.0 | 27.0 |
| ≥ 1.4 | 78.1 | 75.6 | 75.0 | 63.3 | 93.3 | 47.7 | 100.0 | 58.4 |
| ≥ 2.0 | 78.1 | 78.6 | 73.1 | 65.6 | 93.3 | 56.2 | 100.0 | 60.6 |
| ≥ 2.1 | 72.0 | 82.4 | 69.2 | 66.7 | 88.3 | 59.2 | 90.0 | 69.3 |
| ≥ 2.3 | 65.9 | 87.8 | 61.5 | 74.4 | 81.7 | 64.6 | 90.0 | 73.0 |
| ≥ 2.5 | 61.0 | 90.8 | 55.8 | 78.9 | 80.0 | 69.2 | 90.0 | 81.0 |
| ≥ 3.2 | 48.8 | 93.9 | 48.1 | 84.4 | 73.3 | 79.2 | 90.0 | 87.6 |
| ≥ 3.4 | 40.2 | 94.7 | 36.5 | 88.9 | 70.0 | 80.8 | 40.0 | 96.0 |
| ≥ 4.6 | 14.6 | 99.2 | 21.2 | 94.4 | 30.0 | 93.1 | 20.0 | 98.2 |
HCV: hepatitis C virus; MOSAIC: MSM (men who have sex with men) Observational Study of Acute Infection with hepatitis C; STI: sexually transmitted infection; UK: United Kingdom.
a Results are shown only for the cut-offs that were available in all four studies.