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RCAS-PyMT-induced tumors in p53 null mice. (A) H&E-stained tissue sections demonstrating the histologic features of p53-deficient liver tumors. Three regions of a single tumor are shown. (B) Histologic features of lung metastasis identified in the same animal. Note that the metastasis most closely resembles region 2 of the primary tumor. (C) Detection of PyMT RNA in the lung metastasis by in situ hybridization with 33P-labeled antisense PyMT RNA.
