TABLE 1.

Tumor induction by RCAS-PyMT in albumin-tv-a transgenic mice^a

Albumin-tv-a transgene	p53 status	Tumor incidence	Metastasis
−	+/+	0/11	N/A
+	+/+	17/26	1/17
+	+/−	14/38	1/14
+	−/−	18/43	6/16

^aIncidence of grossly visible tumors in albumin-tv-a transgenic mice detected after sacrifice. p53^+/+ and p53^+/− mice were sacrificed at either 4 or 6 months of age. p53^−/− mice were sacrificed at either 4 months of age or upon the detection of lymphomas or sarcomas, whichever came first. N/A, not applicable.