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Extended regulatory network for pluripotency modeled in [32]. The network includes, in addition to the core pluripotency factors Oct4, Sox2, and Nanog, Cdx2 and Gata6 to represent trophectoderm and endoderm commitment through Oct4-Cdx2 and Nanog-Gata6 interactions, respectively, and the nuclear receptor Gcnf. Green and purple ovals represent pluripotency and differentiation genes, respectively.
