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. 2017 Jun 15;108(6):1223–1230. doi: 10.1111/cas.13241

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© 2017 The Authors. Cancer Science published by John Wiley & Sons Australia, Ltd on behalf of Japanese Cancer Association.

This is an open access article under the terms of the Creative Commons Attribution‐NonCommercial‐NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.

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Overall survival (OS; upper panels) and progression‐free survival (PFS; lower panels) estimated by Kaplan–Meier analyses in subgroups of Japanese patients with previously untreated advanced melanoma given nivolumab (n = 23). OS (a) and PFS (d) in subgroups stratified by lactate dehydrogenase (LDH) levels at baseline (normal [≤ upper limit of the normal range [ULN], abnormal [>ULN]). Red and blue lines represent patients with low and high levels of LDH, respectively. OS (b) and PFS (e) in subgroups stratified by treatment‐related select adverse events (TSAEs). Red and blue lines represent patients with and without TSAEs, respectively. OS (c) and PFS (f) in subgroups stratified by vitiligo during treatment. Red and blue lines represent patients with and without vitiligo, respectively. CI, confidence interval; HR, hazard ratio; NR, not reached.