Table 3.
Clinical course of classical Hodgkin lymphoma‐type methotrexate‐associated lymphoproliferative disorders after discontinuation of methotrexate
| Patient No. | Response after MTX discontinuation | Regrowth after MTX discontinuation | Period from MTX‐LPD diagnosis to initiation of chemotherapy (months) | Response to chemotherapy | Final state | Final outcome |
|---|---|---|---|---|---|---|
| 1 | Exacerbation | — | 0.7 | Progressive disease | Bacterial pneumonia during chemotherapy | Dead |
| 2 | Reduction | Regrowth | 7.3 | Complete response | CR state after the chemotherapy | Alive |
| 3 | Exacerbation | — | 2.4 | Complete response | CR state after the chemotherapy | Alive |
| 4 | Reduction | Regrowth | 5.7 | Complete response | CR state after the chemotherapy | Alive |
| 5 | No change | — | 0.7 | Complete response | CR state after the chemotherapy | Alive |
| 6 | No change | — | 0.5 | Complete response | CR state after the chemotherapy | Alive |
| 7 | Reduction | Regrowth | 23.5 | Complete response | CR state after the chemotherapy | Alive |
| 8 | No change | — | 0.5 | Complete response | CR state after the chemotherapy | Alive |
| 9 | Reduction | Regrowth | 21.5 | Complete response | CR state after the chemotherapy | Alive |
| 10 | Reduction | None | None | — | Spontaneous remission | Alive |
| 11 | Reduction | Regrowth | 15.1 | Complete response | CR state after the chemotherapy | Alive |
| 12 | Reduction | Regrowth | 9.5 | Complete response | CR state after the chemotherapy | Alive |
| 13 | Reduction | None | None | — | Spontaneous remission | Alive |
| 14 | No change | — | 0.9 | Complete response | CR state after the chemotherapy | Alive |
| 15 | Reduction | None | None | — | Spontaneous remission | Alive |
| 16 | Reduction | None | None | — | Spontaneous remission | Alive |
| 17 | Reduction | Regrowth | 7.6 | Complete response | CR state after the chemotherapy | Alive |
CR, complete response; MTX, methotrexate; MTX‐LPD, methotrexate‐associated lymphoproliferative disorders.