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. 2017 Jun 2;108(6):1135–1143. doi: 10.1111/cas.13234

Figure 4.

Figure 4

Trametinib (TB) induces ferritin expression and represses TfR1 and iron regulatory protein‐2 (IRP2) expression in colorectal cancer cell lines. Ferritin, TfR1, p‐ERK and IRP2 protein expression changes in (a) HCT116, (b) SW480, (c) RKO and (d) HT29 cells co‐cultured with or without TB (10 nM). Data expressed as mean fold change in protein expression, normalized to non‐treated control cells and β‐actin loading control. Error bars denote ± SEM with * representing statistical significance when P < 0.05 and n = 6. Arbitrary (arb.).