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. 2017 May 25;108(6):1119–1127. doi: 10.1111/cas.13237

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© 2017 The Authors. Cancer Science published by John Wiley & Sons Australia, Ltd on behalf of Japanese Cancer Association.

This is an open access article under the terms of the Creative Commons Attribution‐NonCommercial License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.

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Regulation of PD‐L1 expression by ZEB1 in the TE8 cell line. TE8 cells were transfected by two different siRNAs directed against ZEB1 or nontargeting (NT) siRNA for 48 h and (a) ZEB1, (b) PD‐L1 and (c) E‐cadherin mRNA expression levels were examined by quantitative real‐time PCR. The results are expressed as fold mRNA expression levels of NT siRNA treated cells (arbitrarily defined as 1) (*P < 0.001, **P < 0.05). (d, e) Intracellular expression of ZEB1 (d) and surface expression of PD‐L1 (e) in cells transfected with NT siRNA or siZEB1 and subjected to IFN‐γ stimulation. (f) Western blotting analysis of the indicated proteins in cells transfected with NT siRNA or siRNA targeting ZEB1 and subjected to IFN‐γ stimulation.