Table 1.
Clinicopathological features according to PD‐L1 expression in patients with esophageal squamous cell carcinoma who underwent esophagectomy
| Factor | PD‐L1 negative (n = 33) | PD‐L1 positive (n = 57) | P‐value | |
|---|---|---|---|---|
| Age (mean) | 62.1 | 63.0 | 0.4382 | |
| Sex (male/female) | ||||
| Male | 31 (93.9) | 49 (85.9) | 0.2460 | |
| Female | 2 (6.1) | 8 (14.1) | ||
| Differentiation of squamous cell carcinoma | ||||
| Well/moderately | 27 (81.8) | 46 (80.7) | 0.8960 | |
| Poorly | 6 (18.2) | 11 (19.3) | ||
| Pathological depth of tumor invasion | ||||
| T < 3 | 26 (78.7) | 26 (45.6) | 0.0021 | |
| T ≥ 3 | 7 (21.3) | 31 (54.3) | ||
| Pathological lymph node metastasis | ||||
| pN(−) | 20 (60.6) | 24 (42.1) | 0.0906 | |
| pN(+) | 13 (39.4) | 33 (57.9) | ||
| ly | (−) | 19 (57.5) | 22 (38.5) | 0.0815 |
| (+) | 14 (42.5) | 35 (61.5) | ||
| v | (−) | 24 (72.7) | 37 (65.0) | 0.4446 |
| (+) | 9 (27.3) | 20 (35.0) | ||
| EMT | (−) | 26 (78.7) | 25 (43.8) | 0.0013 |
| (+) | 7 (21.3) | 32 (56.2) | ||
| CD8 | Low | 12 (36.4) | 38 (66.7) | 0.0053 |
| High | 21 (63.6) | 19 (33.3) | ||
| ZEB1 | Low | 24 (72.7) | 29 (50.9) | 0.0397 |
| High | 9 (27.3) | 28 (49.1) | ||
The numbers in parentheses indicate percentages.
EMT, epithelial mesenchymal transition; ly, lymphatic permeation; PD‐L1, programmed death‐ligand 1; v, venous permeation.