Fig. 1.

Synthetic and clinical data sets used to evaluate CFs. a Synthetic data set was created by applying 30 equal pressure increments to an idealized finite element (FE) model to generate 30 deformed geometries ‘frames’, b the clinical data set combines an averaged pressure trace with FE meshes that capture the deformation calculated from registration of the cine MRI frames. Combined, these provide a displacement and pressure measurement for each MRI frame recorded over the cardiac cycle. In our analysis only the diastolic frames, where a passive inflation approximation is relevant, are utilized (marked as diastolic window of interest)