Table 4.
Point mutations that give rise to amino acid changes between the three main Danish clusters
| Position in the partial NS1 sequence: | Saeby cluster Nucleotides: Amino acid: |
Holstebro cluster Nucleotides: Amino acid: |
Zealand cluster Nucleotides: Amino acid: |
|---|---|---|---|
| 32–34 | CAA: Q | CAC: H | CAA: Q |
| 50–52 | TTT: F | TTG/TTA: L | TTG: L |
| 53–55 | ATA: I | CTT: L | ATT: I |
| 59–61 | AGA: R | AGA: R | AAA: K |
| 62–64 | CTA: L | ATA: I | ATA: I |
| 80–82 | GTT: V | TGT: C | GCT: A |
| 104–106 | GAC: D | AAC/GAC: N/D | GAC: D |
| 107–109 | ATA: I | CAA: Q | CAA: Q |
| 131–133 | GAT: D | GCT/GAT: A/D | GCT: A |
| 140–142 | AAG: K | GAT/AAT/AGT: D/N/S | GAT: D |
| 230–232 | AAC: N | ACC: T | AAC: N |
| 248–250 | ATT: I | CTA/ATA/ATG: L/I/M | ATG: M |
| 278–280 | AAT: N | CAT: H | CAT: H |
| 287–289 | GGT: G | AGT: S | AAT: N |
| 302–304 | TTT: F | TAT: Y | TAT: Y |
| 323–325 | ATT: I | TTA: L | GGT: V |
| 326–328 | ATT: I | ATT: I | GTT: V |
The three major strains of Denmark are included: the Saeby strain, the Holstebro strain and the Zealand strain. Mutations unique to each single strain are marked with bold data
Nucleotides: A: adenine, G: guanine, C: cytosine and T: thymine
Aminoacids: A: Alanine, C: cysteine, D aspartic acid, F: phenylalanine, G: glycine, H: histidine, I: isoleucine, K: lysine, L: leucine, M: methionine, N: asparagine, P: proline, Q: glutamine, R: arginine, S: serine, T: threonine, V: valine and Y: tyrosine