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. 2017 Jun 22;4(3):ENEURO.0192-17.2017. doi: 10.1523/ENEURO.0192-17.2017

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Copyright © 2017 Askew et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license, which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.

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Figure 11. — Cortical microinjection of positive allosteric modulator, NS9283, enhanced TINN-evoked responses in A1. A, Example of NN-evoked current sink in A1 enhanced by intracortical microinjection of NS9283, and subsequently by systemic nicotine (left); graph (right) shows response magnitudes before and after NS9283 microinjection. B, Group data (n = 10) of NS9283 effects on NN-evoked responses (left), implicating enhancement by endogenous ACh. Graph on right correlates effect of NS9283 microinjection (post-NS/pre-NS ratio) with that of systemic nicotine (post-nic/pre-NS ratio), all notch widths included. Correlation reflects similar effects of both drugs, including enhancement at narrow notch widths and suppression at intermediate notch widths.