Figure 2.

Systemic nicotine enhanced responses to narrow-notch stimuli and tone stimuli, and reduced responses to intermediate-notch stimuli in A1. A, Example of nicotine effect on TINN-evoked current sinks in L4 (left) and derived functions (right). B, Group data (n = 23) demonstrating nicotinic enhancement of responses to narrow-notch stimuli and reduction of responses to intermediate-notch stimuli (left). Data are normalized to prenicotine plateau of sigmoid function. Group data are also plotted as postnicotine/prenicotine response ratios versus notch width (right), indicating differential nicotinic effects at narrow versus intermediate notch sizes. C, Group data (n = 18) demonstrating nicotinic enhancement of responses to CF tone contained within TINN stimulus (sigmoidal curves) and to CF tone presented alone (separated data points on right).