FIG. 5.

Mouse DMPK tail 1 and 2 anchors have different sequence arrangements and hydrophobicity profiles. (A) Hydrophobicity plots of mDMPK tails 1 and 2. The average hydrophobicity of the assigned TMD (25) is indicated. (B) Comparison of DMPK tail 1 and 2 sequences with ER and MOM targeting sequences of known tail-anchored proteins. Putative TMDs are boxed, and basic residues are shown in bold. Amino acid numbering for mouse and human DMPK isoforms is indicated (see also Fig. 1A).