Table 3.
Subgroup and overall analysis for the association between genetic effects of rs11200638 polymorphism and anti-angiogenesis treatment of exudative AMD
| Heterogeneity | |||||||
|---|---|---|---|---|---|---|---|
| Polymorphism | Subgroup | Study(n) | OR (95% CI) | P Value | P Value | I 2% | |
| GG + GA vs AA | Ethnic | Caucasian | 4 | 1.4 (0.81, 2.57) | 0.22 | 0.05 | 62 |
| Overall | 5 | 1.61 (0.96, 2.70) | 0.07 | <0.01 | 68 | ||
| GG vs AA | Ethnic | Caucasian | 3 | 1.03 (0.71, 1.49) | 0.87 | 0.99 | 0 |
| Overall | 4 | 1.16 (0.84, 1.60) | 0.37 | 0.39 | 3 | ||
| GA vs AA | Ethnic | Caucasian | 3 | 1.10 (0.78, 1.55) | 0.58 | 0.8 | 0 |
| Overall | 4 | 1.20 (0.90, 1.58) | 0.21 | 0.21 | 32 | ||
| G vs A | Ethnic | Caucasian | 3 | 1.01 (0.84, 1.20) | 0.934 | 0.99 | 0 |
| Overall | 4 | 1.04 (0.69, 1.56) | 0.87 | <0.01 | 75 | ||
AMD age-related macular degeneration, OR odds ratio, CI confidence interval