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. 2017 Jun 6;6:43–53. doi: 10.1016/j.omtm.2017.05.009

Figure 1.

Figure 1

In Vitro Uptake of BMN 250 in Normal Mouse Hippocampal Neurons

(A) Representative confocal images of cultured mouse hippocampal neurons treated with Alexa Fluor 488-labeled BMN 250 (green) and LysoTracker red (red), showing localization of NAGLU signals to lysosomes (yellow), with arrows indicating representative co-localized signals. (B) IGF2/mannose 6-phosphate receptor-dependent uptake of BMN 250 by normal mouse neurons was significantly inhibited by IGF2. NAGLU activity in cell lysates, expressed as the fold elevation (mean ± SD, n = 3) above normal levels. ***p < 0.001.