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. Author manuscript; available in PMC: 2017 Jun 22.
Published in final edited form as: Chem Res Toxicol. 2015 Sep 21;28(10):1903–1913. doi: 10.1021/acs.chemrestox.5b00105

Figure 9. Proposed Mechanism of Action of Artesunate in Lung Diseases.

Figure 9

As supported by our data, artesunate is able to bind to various proteins related to glucose metabolism, mRNA and gene expressions, ribosomal regulatory proteins, stress responses proteins, structural proteins and others. Artesunate also led to modulation of multiple nuclear transcription factors, related to major inflammatory signalling cascades. This in turn leads to the alteration of various pro-inflammatory and anti-inflammatory gene expressions, which results in the suppression of the respective hallmarks of asthma.