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Feasibility studies of cycloaddition and RCM reaction in single and two-step protocol.
| RCM product | Two-step protocola | Direct protocola | ||||||
| CuAAC Yield (%) | Grubbs cat. (mol %) | RCM yield (%) | Combined yield (%) | Grubbs cat. (mol %) | Yield (%) | |||
| 4e | 76 | (5+3) | 40 | 31 | (5+5) | 32 | ||
| 4f | 78 | 5 | 39 | 30 | 5 | 29 | ||
| 4g | 92 | (5+3) | 92 | 85 | 5 | 49 | ||
| 4h | 91 | 5 | 92 | 84 | 5 | 80 | ||
aIsolated yield after column chromatography.
