Figure 2.

Prion–inducing activity of Lsb2 coincides with yeast adaptation to higher growth temperature. Schematic shows phylogenetic relationships among some members of the Saccharomyces sensu stricto genus. The preferred growth temperature of each species is indicated.^74,75 CLUSTALW-formatted multiple sequence alignment of C-terminal of Lsb1/Lsb2 is shown. Difference in amino acids is indicated in red (Lsb2) and blue (Lsb1). Residue essential for prion induction is bordered. Amyloid stretch hexapeptide is underlined.