Figure 3.

FTH Prevents Liver Glucose Metabolism from Shifting Toward Glycolysis in Detriment of Gluconeogenesis

(A) Blood glucose in Mx1^CreFth^Δ/Δ mice subjected to CLP and receiving pyruvate (n = 6) or vehicle (n = 7). Mean ± SD from two independent experiments. Numbers in gray indicate live/total mice at different time points.

(B) Survival of the same mice as in (A).

(C) Targeted metabolomics of the liver and flux balance analysis for ATP generation using data integration into a reconstructed metabolic network iMM1415 (Sigurdsson et al., 2010).

Data are shown as mean ± SD (n = 5 mice per group). DHAP, dihydroxyacetone phosphate; F6P, fructose 6-phosphate; F16P, fructose-1,6-bisphosphate; GAP, glyceraldehyde 3-phosphate; G6P, glucose 6-phosphate; 13bPG, 1,3-bisphosphoglycerate; 2PG, 2-phosphoglycerate; 3PG, 3-phosphoglycerate; PEP, phosphopyruvate. ^∗p < 0.05; ^∗∗p < 0.01; ^∗∗∗p < 0.001.

See also Figure S5 and Tables S1 and S2.