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. Author manuscript; available in PMC: 2018 Feb 3.
Published in final edited form as: Science. 2017 Feb 3;355(6324):499–503. doi: 10.1126/science.aal5175

Fig. 1. Construction of α-chiral centers via C–H activation.

Fig. 1

(A) Enzymatic approach. (B) Organometallic approach. (C) Challenges in chiral differentiation. DG, directing group; Me, methyl group; t-Bu, tert-butyl group; CoA, Coenzyme A; R, alkyl or aryl group; pin, pinacolato group.