Table 2.
Summarized list of recently used polymer nanoparticles and their modifying ligand for targeted gene delivery in lung cancer
| Targeting ligand/receptor | Polymer(s) | Nucleic acid therapeutic(s) | Lung cancer cell line | Reference(s) |
|---|---|---|---|---|
| Folic acid/FRA | Hyperbranched polyspermine | Plasmid DNA | A549 | [98] |
| Folic acid/FRA | Polyspermine nanoplex modified with poly(ethylene glycol) (PEG) diacrylate (SPE-alt-PEG) | Plasmid DNA | A549 | [99] |
| Folic acid/FRA | Chitosan-graft-PEI | shRNA | A549 | [100] |
| RGD/Integrin αvβ3 | Chitosan-PEI | siRNA | H1299 | [108] |
| RGD/integrin αvβ3 | PLGA | Plasmid DNA | H1299 | [109] |
| EGFR ligand | Chitosan | siRNA | A549 | [117, 119] |
| EGFR ligand | LPEI | siRNA | SPC-A1 | [118] |
| Hyaluronic acid/CD44 | HA-PEI/PEG | siRNA | A549 | [125, 126] |
| Hyaluronic acid and EGFR ligand/CD44 and EGFR | Hyaluronic acid (HA)-based nanoparticles | miRNA and plasmid DNA | SK-LU-1 | [127] |