Table 3.
GOBPs1 represented by up- and down-regulated genes by ZP or E2 DEGs
| Pathway | Up |
Down |
|||
|---|---|---|---|---|---|
| E2 up | ZP up | E2 Down | ZP down | ||
| Regulation of cell proliferation | 4.78E-07 | 1.00E+00 | 1.16E-02 | 1.00E+00 | |
| Response to hormone stimulus | 3.18E-06 | 1.43E-05 | 8.59E-04 | 1.00E+00 | |
| Response to nutrient levels | 8.68E-05 | 2.40E-05 | 1.98E-02 | 1.00E+00 | |
| Epithelial cell differentiation | 1.79E-04 | 3.80E-02 | 1.00 E +00 | 1.00E+00 | |
| Epithelium development | 2.20E-04 | 5.24E-02 | 3.79E-02 | 1.00E+00 | |
| Response to drug | 3.78E-04 | 1.33E-03 | 1.00E+00 | 1.00E+00 | |
| Homeostatic process | 1.24E-03 | 1.74E-03 | 3.75E-02 | 1.00E+00 | |
| Response to hypoxia | 4.48E-03 | 3.08E-02 | 1.18E-03 | 1.00E+00 | |
| Protein complex assembly | 8.63E-03 | 2.78E-02 | 3.57E-02 | 1.00E+00 | |
| Aging | 8.79E-03 | 5.54E-02 | 2.41E-02 | 1.00E+00 | |
| Rhythmic process | 1.00E+00 | 6.91E-02 | 3.13E-02 | 1.85E-02 | |
| Skeletal system development | 1.00E+00 | 1.00E+00 | 6.90E-04 | 8.21E-02 | |
Values are presented as enrichment p-values.
GOBPs, gene ontology biological processes; ZP, zinc pyrithione; E2, 17β-estradiol; DEGs, differentially expressed genes.
1
GOBPs with p<0.1 were considered as the ones represented by such genes.