OCT images of human coronary plaques in vivo. (A) Artery wall with intimal hyperplasia. (B) Fibrous plaque showing a thickened intima. (C) Calcific plaque demonstrating a heterogeneous, signal poor region (orange arrows) with clearly demarcated borders. (D) OCT fibroatheroma, showing a signal poor region with poorly defined borders (yellow arrows), consistent with lipid, and overlying tissue, known as the fibrous cap (red arrows). Tick marks in (A), (B), and (D) – 250 µm. Tick marks in (C) – 500 µm.