(a) Tethered capsule endomicroscopy (TCE) device. TCE images obtained from a healthy volunteer in vivo: (b, c) in the normal esophagus (squamous epithelium (E), muscularis mucosa (MM), lamina propria (L), submucosa (S) containing blood vessels (arrowheads), inner muscularis (IM), outer muscularis (OM) and myenteric plexus (MP)), and (d, e) in the stomach showing characteristic glandular ‘pits’ (arrowheads). (f, g) TCE image obtained from a patient with BE in vivo. The asterisks indicate a multiple reflection artifact. Tick marks, (b, d, f) 1 mm; scale bars, (c, e, g) 0.5 mm. (Figure and caption adapted from [75].)