Fig. 1.

(A) The schematic of hand-held DOS/DCS probe and the way it is applied on the tumor. The probe schematic only contains the location of the fibers that have been used in this study. The probe is designed to be self-calibrating, featuring a miniaturized semicircle scheme for assessing the source-detector coupling coefficients. There is a DOS source in one end of diameter and also a self-calibration source in the center of semicircle. The DOS detectors are located on the circumference of this semicircle that makes them equidistant from the calibration source. (B) An anesthetized nude mouse with a renal tumor and the optical probes (control and main) on top of the shoulder muscle and tumors with a photograph of the main probe tip on the top. Since the illuminated light to different fibers was not homogeneous they have different brightness and visibility. The smaller dots (seven locations) correspond to single mode fibers (DCS detector fibers). Not all the sources and detectors of the main probe are used in this study.