TABLE 1.
Characteristics of invasive β-hemolytic streptococci isolated in a 6-month period in 40 Argentinian centers
| Subtypea | No. of adult patients | No. of children | No. of cases with age, STSS, and survival unknown | No. of STSSb
|
No. of deathsb
|
Serologic featuresc | sof typed | ||
|---|---|---|---|---|---|---|---|---|---|
| A | P | A | P | ||||||
| emm1.0 | 2 | 13 | 1 | 3 | 3 | T1, M1, OF− | PCR neg | ||
| emm3.1 | 1 | 1 | T3, M3, OF− | PCR neg | |||||
| emm4.0 | 1 | 1 (newborn) | 2 | T4, M4, AOF4 | sof4 | ||||
| emm9.0 | 1 | T14, MNT, AOFNT | ND | ||||||
| emm11.0 | 1 | T11/12, MNT, AOF25 | sof25 | ||||||
| emm12.0 | 3 | 2 | 2 | 1 | 1 | 1 | T12, M12, OF− | sof12 | |
| emm18.7 | 1 | 1 | TNT, M18, OF− | PCR neg | |||||
| emm22.0 | 1 | 1 | T11/12, M22, AOF22 | sof22 | |||||
| emm33.0 | 1 | T3/B, M33, OF− | PCR neg | ||||||
| emm43.5 | 1 | 1 | TNT, M43, OF− | PCR neg | |||||
| emm58.0 | 2 | T8/25/1, AOF58 | sof58 | ||||||
| emm66.0 | 1 | 1 | T12, M66, AOF66 | sof66 | |||||
| emm75.0 | 3 | 1 | 1 | T25/1, M75, AOF75 | sof75 | ||||
| emm78.0 | 1 | T11/12, MNT, AOF78 | sof78 | ||||||
| emm82.0 | 2 | 1 | 2 | 2 | T5/27/44, MNT, AOFNT | sof82 | |||
| emm83.1 | 1 | T3/13/B, OF− | PCR neg | ||||||
| emm87.0 | 1 | 3 | 1 | T28, M87, AOF87 | sof87 | ||||
| emm89.0 | 1 | T11, M89, AOF89 | sof89 | ||||||
| emm92.0 | 1 | 1 | 1 | 1 | T8/25/1, MNT, AOF92 | sof92 | |||
| emm94.0 | 1 | T3/13, MNT, AOFNT | sof94 | ||||||
| emm123.0 | 1 | T9/3/B, MNT, OF− | PCR neg | ||||||
| Not typed | 4 | 2 | ND | ND | |||||
| stC1400.0 | 1 | NA | NA | ||||||
| stC6979.0 | 1 | NA | NA | ||||||
| stC57.0 | 1 | NA | NA | ||||||
| stC36.3 | 3 | NA | NA | ||||||
| stG6.0 | 3 | 1 | 2 | 1 | 1 | NA | NA | ||
| stG6.1 | |||||||||
| stG10.0 | 2 | 2 | NA | NA | |||||
| stG480.0 | 4 | 1 | 1 | 2 | NA | NA | |||
| stG485.0 | 1 | NA | NA | ||||||
| stG4222.0 | 1 | NA | NA | ||||||
All emm designations represent S. pyogenes. stC or stG designations indicate either group C or group G S. dysgalactiae subsp. equisimilis except in one instance described in footnote b. Six S. pyogenes were not available for typing (Not Typed). For each emm type (or st) representing two or more isolates, at least two were subjected to emm amplicon sequencing, and each singly occurring emm type was directly determined through sequence analysis.
A, adult patients; P, pediatric patients. Two sets of each category are provided to accommodate two sets of results of sequencing.
All isolates were T typed and subjected to opacity factor production test (OF). At least the majority of isolates were M serotyped and subjected to anti-opacity factor (AOF) testing. Representative results are shown and no discrepant results were found.
Specific sof sequence types are result of sequence typing at least one random isolate within this emm type. neg, negative; ND, not done; NA, not available.
One isolate was identified as a group A Streptococcus dysgalactiae subsp. equisimilis.