Figure 1.

Targeting the CYFIP1-WASF3 interface suppresses metastasis in vivo. (A, above) Scheme of treatment with the WAHM1 peptide. Injections of stapled peptides began 2 weeks after the injection of tumor cells and continued for a further 5 weeks. (A, below) Primary tumor volume was measured at weekly intervals where there was a significant reduction in tumor size after 5 weeks (*P < .05). (B) Bioluminescence imaging after 5 weeks suggests more extensive spread of the tumor in animals treated with vehicle alone compared with animals treated with the WAHM1 peptide. (C) On completion of the experiments, tumor weight was significantly smaller in the WAHM1-treated animals as was the overall body weight. (D) On completion of the treatment regimen, analysis of the lungs shows a significant reduction in the number of surface tumor nodules in the WAHM1-treated animals.