Fig. 1.

Lesion overlap map, CBF map and jICA results for component six. Panel A: Lesion overlap map derived using the fuzzy clustering method (Seghier et al., 2008). Individual participants' lesions were overlaid onto an MNI template brain using the MRIcron software. Map displays voxels in which lesion overlap occurred in a minimum of a third of the WA group. Axial slices are presented with MNI Z coordinate. Panel B: Cerebral Blood Flow map displaying the average CBF (ml/100 ml/min) in the WA group. Panel C: jICA result displaying component six. Map displays regions where presence of lesion (red) correlated with reduction in CBF (green). Overlapping areas of lesion and hypoperfusion are displayed in yellow.