TABLE 5.

Estimated specificities of endocervical diagnostic tests for C. trachomatis stratified by subjects' characteristics

Characteristics of subjects tested	% Specificity (95% CI)a for cervical test type:
	PACE2		LCR	PCR
	Culture-PCR	Culture-LCR	Culture-PCR	Culture-LCR
All subjects	99.7 (99.5, 99.9)	99.7 (99.5, 99.9)	99.3 (98.9, 99.8)	99.7 (99.6, 99.9)
Age (yr)
<20	100 (99.5, 100)b	100 (99.4, 100)b	98.9 (98.0, 99.9)	99.8 (99.4, 100)
≥20	99.6 (99.4, 99.9)	99.6 (99.4, 99.9)	99.4 (99.0, 99.8)	99.7 (99.5, 99.9)
Mucopurulent endocervical discharge
Present	100.0 (99.1, 100)	100.0 (99.1, 100)	98.1 (96.9, 99.4)c	99.7 (98.7, 100)
Absent	99.6 (99.3, 99.9)	99.6 (99.3, 99.9)	99.5 (99.1, 99.8)	99.8 (99.6, 100)
Current menses
Yes	99.5 (98.6, 100)	99.5 (98.6, 100)	99.5 (98.6, 100)	99.5 (98.6, 100)
No	99.7 (99.5, 99.9)	99.7 (99.5, 99.9)	99.3 (98.8, 99.8)	99.7 (99.6, 99.9)
N. gonorrhoeae detected at cervix
Yes	99.2 (97.9, 100)	99.2 (97.7, 100)	97.0 (94.1, 99.9)	100.0 (97.6, 100)
No	99.8 (99.5, 100)	99.8 (99.5, 100)	99.3 (98.9, 99.7)	99.8 (99.5, 100)
Hematuria
Yes	99.5 (99.1, 100)	99.5 (99.1, 100)	99.4 (98.9, 99.9)	100.0 (99.6, 100)c
No	99.7 (99.5, 100)	99.7 (99.5, 100)	99.4 (99.0, 99.9)	99.7 (99.4, 99.9)
Urine leukocyte esterase
Positive	99.8 (99.5, 100)	99.8 (99.5, 100)	99.3 (98.8, 99.8)	99.9 (99.7, 100)
Negative	99.7 (99.4, 100)	99.7 (99.4, 100)	99.4 (98.8, 99.9)	99.7 (99.3, 100)

^aAdjusted for variation in test performance across centers. Performance is defined as described in the text using two reference standards (culture-PCR and culture-LCR); estimates are reported separately for each. CI, confidence interval.

^bP = 0.04 for comparison of test specificities in the presence versus absence of subject characteristic noted.

^cP = 0.05 for comparison of test specificities in the presence versus absence of subject characteristic noted.