Table 1. Bivariate analyses of baseline variables of deep rPH, lobar rPH and patients without ICH.
| Deep rPH n = 9 |
Lobar rPH n = 25 |
No ICH n = 900 |
p value Deep rPH vs No ICH | p value Lobar rPH vs No ICH | |
|---|---|---|---|---|---|
| Age, years, median (IQR) | 78 (73–85) | 78 (72–84) | 77 (67–83) | 0.46* | 0.39* |
| Men, n (%) | 3/9 (33.3) | 13/25 (52) | 477/900 (53) | 0.32† | 0.99† |
| Hypertension, n (%) | 5/9 (55.5) | 17/25 (68) | 651/900 (72.3) | 0.27† | 0.65† |
| Diabetes, n (%) | 3/9 (33.3) | 4/25 (16) | 213/900 (23.6) | 0.45† | 0.47† |
| Atrial fibrillation, n (%) | 3/9 (33.3) | 6/25 (24) | 213/900 (23.6) | 0.45† | 0.99† |
| TIA/Stroke, n (%) | 2/9 (22.2) | 4/25 (16) | 130/900 (14.4) | 0.62† | 0.77† |
| Antiplatelets, n (%) | 4/9 (44.4) | 13/25 (52) | 330/900 (36.6) | 0.73† | 0.14† |
| Anticoagulants, n (%) | 2/9 (22.2) | 1/25 (4) | 60/900 (6.6) | 0.12‡ | 0.99‡ |
| Baseline NIHSS, median (IQR) | 12 (6–15.5) | 11 (5–19) | 10 (6–17) | 0.88* | 0.66* |
| Onset-to-needle time (min), median (IQR) | 150 (125–257) | 144 (97–187) | 135 (99–180) | 0.08* | 0.53* |
| Platelet count, 109/L, median (IQR) | 210 (162–236) | 208 (180–243) | 215 (177–257) | 0.69* | 0.43* |
| aPTT (ratio), median (IQR) | 0.9 (0.8–0.9) | 0.92 (0.85–0.94) | 0.89 (0.83–0.94) | 0.70* | 0.44* |
| INR, median (IQR) | 1.0 (1.0–1.2) | 1.0 (0.9–1.1) | 1.0 (0.9–1.1) | 0.42* | 0.92* |
| INR anticoagulants, median (IQR) | 1.4 | 1.3 | 1.3 (1.2–1.5) | 0.76* | 0.95* |
| Hypertension 24h, n (%) | 7/9 (77.7) | 6/23 (26) | 206/884 (23.3) | <0.001† | 0.60† |
| Hyperglycemia 24h, n (%) | 2/9 (22.2) | 3/23 (13) | 180/789 (22.8) | 0.99† | 0.15† |
| 1 CMB, n (%) | 1/5 (20) | 7/13 (53.8) | 29/364 (7.9) | 0.34‡ | <0.001‡ |
| >1 CMB, n (%) | 0/5 (0) | 4/13 (30.7) | 16/359 (4.4) | 0.99‡ | 0.003‡ |
| Lobar CMB, n (%) | 1/5 (20) | 7/13 (53.8) | 11/364 (3.0) | 0.15‡ | <0.001‡ |
| Deep CMB, n (%) | 0/5 (0) | 0/13 (0) | 5/364 (1.3) | 0.99‡ | 0.99‡ |
| Mixed CMB, n (%) | 0/5 (0) | 0/13 (0) | 9/364 (2.4) | 0.99‡ | 0.99‡ |
| Severe Leukoaraiosis, n (%) | 0/5 (0) | 10/13 (76.9) | 153/360 (42) | 0.07‡ | 0.02‡ |
| CSS, n (%) | 1/5 (20) | 1/13 (7.6) | 4/354 (1.1) | 0.06‡ | 0.16‡ |
Values are expressed as absolute counts and percentage for categorical variables and median and interquartile range (IQR) for continuous variables. P values are given for difference between patients with deep or lobar remote parenchymal hemorrhage (rPH) and patients without any intracranial hemorrhage (ICH). The p values were obtained by Mann-Whitney U Test (*), χ2 Test (†) or Fisher exact test (‡). TIA, indicates transient ischemic attack; NIHSS, National Institutes of Health Stroke Scale; aPTT, activated partial thromboplastin time; INR, international normalized ratio; INR anticoagulants, international normalized ratio in patients who were treated with oral anticoagulants; Hypertension 24h, hypertensive episodes within first 24 hours of intravenous thrombolysis; Hyperglycemia 24h, capillary glucose ≥7.7 mmol/L within the first 24 hours of intravenous thrombolysis; CMB cerebral microbleeds; Severe Leukoaraiosis, a score of 2 or 3 in a simplified scale of Fazekas and Schmidt [9]; CSS, cortical superficial siderosis.