Fig 6. Dynamic contrast-enhanced MRI signal-intensity-time curves for a non-treated (black filled circles) and Ivabradine-treated animal (red open circles) showing the relative signal enhancement in the atherosclerotic vessel wall after contrast injection.

Pharmacokinetic modelling curves are shown as black solid lines (non-treated animals) and gray dotted lines (Ivabradine-treated animals). Enhancement curves for Ivabradine-treated animals show a delayed enhancement compared to non-treated animals, which is indicative for a decrease in plaque microvasculature.