Table 2. Study parameters for the present study.

Parameters are reported as mean values ± standard error. Number of successful experiments that were performed is indicated (^§n = 9, ^lln = 8, ^¶n = 7, ^#n = 6). AUC 7 min and K^trans represent DCE-MRI parameters of the plaque microvasculature. The percentage of RAM11 is a measure of the plaque macrophage content. Used abbreviations: heart rate (HR); blood pressure (BP); Elastica von Gieson (EvG); area-under-the-curve (AUC); ^*p<0.05.

Category	Parameter	Non-treated	Ivabradine-treated	P-value
Cardiovascular	Conscious HR [bpm]	186±7.0§	157±9.3¶	0.03*
	Anesthesia HR [bpm]	164±5.9§	140±6.4¶	0.03*
	Systolic BP [mmHg]	63±3.4§	71±7.9#	0.27
	Diastolic BP [mmHg]	45±3.4§	53±6.8#	0.33
Plaque burden	MR plaque size [mm2]	11.0±0.9ll	10.8±1.1¶	0.54
	EvG intima size [mm2]	6.80±1.03ll	6.61±1.19¶	0.91
Biomechanics	Absolute distension [mm]	0.066±0.017§	0.064±0.018¶	0.84
	Relative distension [%]	1.9±0.4§	1.9±0.3¶	0.84
Plaque vulnerability	AUC 7min [a.u.]	791±60ll	604±44¶	0.03*
	Ktrans [min-1]	0.25±0.02ll	0.17±0.02¶	0.04*
	Microvessel density [mm-2]	12.9±1.8ll	9.8±1.8¶	0.40
	Relative lipid core size [%]	1.7±0.4ll	1.5±0.3¶	0.66
	Relative RAM11 [%]	30.6±1.5ll	17.2±2.9¶	<0.01‡