A, effects of ARE-1, Bic, and Enz on DHT induced KLK3 mRNA in LNCaP/AR cells (top), and baseline (charcoal stripped media) (bottom). B, effects of ARE-1 and Enz against select genes co-regulated by AR and GR in LREX’ cells. C, GSEA analysis in LREX’ cells. Top, DHT enriches for the Androgen Response. Bottom, ARE-1 with DHT negatively enriches for Androgen Response and the UV Response Down. D, ARE-1 treatment of LNCaP cells negatively enriches for Androgen Response and the UV Response Down. * p<0.05.