Fig. 1.

A) Representative GAPDH-normalized immunoblotting images and quantification (n = 4–6 independent samples per group) of proteins related in neuroinflammation processes in the hippocampal extracts of WT, APP/PS1 and APP/PS1-DXI treated 6-month-old mice. B) Immunohistochemistry of ThS of Aβ plaque and GFAP in the brains of 6-month-old APP/PS1 and APP/PS1-DXI treated mice (n = 4–6 independent samples per group, with at least 5 slices analyzed per sample). C) Concentrations of soluble and insoluble human Aβ(1−42) peptides in the cortical extracts in untreated and DXI-treated APP/PS1 mice, expressed as pg/mg of total protein as determined by ELISA; n = 4–6 independent samples per group, with 3 technical replicates per sample (* denotes p < 0.05).