Fig. 3.

Representative GAPDH-normalized immunoblotting images and quantification (n = 4–6 independent samples per group) of key molecules involved in TAU hyperphosphorilation A) Protein levels of TAU, pTAU (T205), pTAU(S396) and pTAU (S404) of WT, APP/PS1 and APP/PS1 treated with DXI, B) Protein levels of c-ABL, p-c-ABL (Y412), CABLES, CDK5 and pCDK5(Y15) of WT, APP/PS1 and APP/PS1 treated with DXI and C) Protein levels of AKT, pAKT, GSK3β AND PGSK3β of WT, APP/PS1 and APP/PS1 treated with DXI (* denotes p < 0.05, ** denotes p < 0.01).