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. 2017 Jun 22;13(6):e1006333. doi: 10.1371/journal.ppat.1006333

Fig 1. Recognition of mycobacterial pathogen-associated molecular patterns (PAMPs) by C-type lectin receptors (CLRs).

Fig 1

Dectin-2 recognizes mannosylated lipoarabinomannan (ManLAM), dendritic cell immunoactivating receptor (DCAR) recognizes phosphatidylinositol mannosides (PIMs), macrophage-inducible C-type lectin (Mincle) and C-type lectin superfamily member 8 (Clecsf8) recognize the glycolipid trehalose 6,6’ dimycolate (TDM), while the mycobacterial ligand of Dectin-1 is yet to be identified. The interaction of the CLRs with mycobacterial PAMPs triggers cytoplasmic signaling and a number of cellular responses. The CLRs signal via Spleen tyrosine kinase (Syk), which associates with the Caspase recruitment domain family member 9 (CARD9)/B-Cell CLL/lymphoma 10 (BCL-10)/Mucosa-associated lymphoid tissue lymphoma translocation protein 1 (MALT1) complex, resulting in the production of pro-inflammatory cytokines and induction of adaptive T-cell immunity.