Table 2. List of scientific questions and related notes.

	Questions	Notes
1)	What are the main water-related pathogens investigated and where do they occur?	Estimate the number of studies for each disease/pathogens under investigation. Ascertain the countries where the disease occurred.
2)	What methods have been used?	Ascertain the key epidemiological methods developed and used so far. Classify the methods in terms of general approaches: such as descriptive phenomenology, process based models (e.g. mechanistic compartmental models or agent based models), statistical analysis of empirical data (e.g. time series analysis) etc.
3)	Is the method applied to investigate the effect of climate change or weather or both?	Assess if the method is actually or potentially applied to climate change and/or weather
4)	Does the type of method depend on the disease/pathogen under investigation?	Ascertain if there is a preferential use of the methods towards particular disease/pathogen and identify possible explanations
5)	What are other key features of the methods?	Identify the specific environmental factors that the method is focusing on (e.g. temperature and rainfall). Ascertain if the method take into account: Temporal variations (e.g. seasonalities and El Niño weather cycles) Evolution of pathogen Human behaviour and/or social and political scenarios (e.g. national economic factors, conflicts, food production, human mobility, demography etc.) Any kind of heterogeneity (e.g. spatial variation, age group, household income) An explicit model for the pathogen dynamic in the reservoir
6)	How were the results assessed?	Establish if and how the method has been validated
7)	What are the limitations of the method according to the authors?	Describe the limitations of the methods identified by the authors