Table 3.
Pathological features of all cases and controls grouped by clustering
| Variables | Blue cluster | Yellow cluster | Gray cluster | Orange cluster | p value |
|---|---|---|---|---|---|
| n | 20 | 18 | 25 | 12 | |
| Diagnosisc | <0.001a | ||||
| Controls | 0 (0.0 %) | 3 (16.7 %) | 21 (84.0 %) | 1 (8.3 %) | |
| PD cases | 0 (0.0 %) | 4 (22.2 %) | 3 (12.0 %) | 3 (25.0 %) | |
| ET cases | 2 (10.0 %) | 11 (61.1 %) | 1 (4.0 %) | 6 (50.0 %) | |
| MSA cases | 9 (45.0 %) | 0 (0.0 %) | 0 (0.0 %) | 1 (8.3 %) | |
| SCA1 cases | 9 (45.0 %) | 0 (0.0 %) | 0 (0.0 %) | 1 (8.3 %) | |
| Purkinje cell counts | 5.7 ± 2.2 Median = 5.4 | 7.9 ± 1.3 Median = 8.1 | 12.0 ± 1.5 Median = 11.7 | 10.7 ± 1.8 Median = 10.1 | <0.001b |
| Torpedo counts | 77.6 ± 67.6 Median = 50.5 | 12.7 ± 7.7 Median = 15.0 | 5.1 ± 7.7 Median = 3.0 | 9.6 ± 6.50 Median = 8.5 | <0.001b |
| CF synaptic density (puncta/100 μm) | 16.9 ± 3.3 Median = 17.0 | 21.9 ± 3.1 Median = 22.00 | 24.8 ± 3.7 Median = 24.00 | 18.5 ± 1.2 Median = 18.00 | <0.001b |
| Percentage of CF extending into outer 20 % ML | 9.7 ± 9.4 Median = 6.0 | 25.9 ± 4.9 Median = 26.0 | 16.5 ± 5.6 Median = 17.0 | 23.1 ± 12.1 Median = 22.8 | <0.001b |
Values represent mean ± standard deviation or number (percentage), and for variables with non-normal distribution, the median is reported as well
CF climbing fiber, ET essential tremor, ML molecular layer, MSA multiple system atrophy, PD Parkinson’s disease, SCA1 spinocerebellar ataxia type 1, VGlut2 vesicular glutamate transporter
a
Chi-square test
b
Kruskal–Wallis test
c
The percentages indicate column percentages