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. Author manuscript; available in PMC: 2017 Jun 22.
Published in final edited form as: Acta Neuropathol. 2016 Oct 4;133(1):121–138. doi: 10.1007/s00401-016-1626-1

Table 4.

Clinical features of essential tremor and Parkinson’s disease cases grouped by yellow and orange clusters

Variables ET cases
p value
Yellow cluster Orange cluster
n 11 6
Age at death (years) 84.0 ± 6.9 86.7 ± 5.5 0.43a
Sex 0.30b
 Men 6 (54.5 %) 1 (16.7 %)
 Women 5 (45.5 %) 5 (83.3 %)
Rest tremor 0.16b
 No 8 (72.7 %) 2 (33.3 %)
 Yes 3 (27.3 %) 4 (66.7 %)
Action/postural tremor
 No 0 (0 %) 0 (0 %)
 Yes 11 (100 %) 6 (100 %)

PD cases
p value
Yellow cluster Orange cluster

n 4 3
Age at death (years) 74.0 ± 5.4 79.33 ± 2.1 0.14a
Sex 1.00b
 Men 3 (75.0 %) 3 (100.0 %)
 Women 1 (25.0 %) 0 (0.0 %)
Rest tremor 0.14b
 No 3 (75.0 %) 0 (0.0 %)
 Yes 1 (25.0 %) 3 (100.0 %)
Action/postural tremor 1.00b
 No 2 (50.0 %) 1 (33.3 %)
 Yes 2 (50.0 %) 2 (66.7 %)

Combined group
(ET and PD cases)
p value
Yellow cluster Orange cluster

n 15 9
Age at death (years) 81.3 ± 7.8 84.2 ± 5.8 0.31a
Sex 0.68b
 Men 9 (60.0 %) 4 (44.4 %)
 Women 6 (40.0 %) 5 (55.6 %)
Rest tremor 0.03b
 No 11 (73.3 %) 2 (22.2 %)
 Yes 4 (26.7 %) 7 (77.8 %)
Action/postural tremor 1.00b
 No 2 (50.0 %) 1 (33.3 %)
 Yes 13 (50.0 %) 7 (66.7 %)

Values represent mean ± standard deviation or number

ET essential tremor, PD Parkinson’s disease

a

Two independent samples t test

b

Chi-square test