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. 2017 Jul;42(7):473–477.

Table 3.

Common Pharmacokinetic Drug Interactions Associated With Torsades de Pointes12

Inhibition of CYP3A4 Inhibition of CYP2D6
Inhibitors Substrates Inhibitors Substrates
Antifungals

  • Itraconazole

  • Ketoconazole

  • Posaconazole

  • Voriconazole

 Amiodarone
Disopyramide
Dofetilide
Pimozide		 Neuropsychiatrics

  • Bupropion

  • Duloxetine

  • Fluoxetine

  • Paroxetine

 Flecainide
Quinidine
Thioridazine
Macrolides

  • Erythromycin

  • Clarithromycin

  • Azithromycin

 Antifungal

  • Terbinafine
Protease inhibitors

  • Atazanavir

  • Darunavir/ritonavir

  • Fosamprenavir

  • Indinavir

  • Nelfinavir

  • Saquinavir

  • Tipranavir

CYP = cytochrome P450