Table 1.

Clinical characteristics of 48 patients with orbital malignant melanoma secondary to a primary tumor elsewhere, classified by the site of primary tumor and the survival interval after presentation with orbital disease.

Sex	Site of primary tumor	Age at presentation with primary tumor	Therapy for primary tumor	Age at secondary orbital disease (years)	Interval between primary therapy and orbital presentation (months)	Side	Treatment for secondary orbital disease	Orbital progression	Systemic progression	Interval between primary therapy and latest follow-up (months)	Survival after orbital treatment (months)	Age at death (years)
M	Choroid	77	Enucleation	79	32	L	Palliation			34	2	79
F	Choroid	89	Incisional biopsy	89	0	L	Incisional biopsy	N	Y	3	3	89
F	Choroid	73	Incisional biopsy	73	0	L	Incisional biopsy + RT	N	N	14	14	75
M	Choroid	49	Local resection	72	282	L	Debulking + chemotherapy	Y	Y	299	17	73
M	Choroid	47	Enucleation	57	114	R	Radiotherapy			138	24	58
F	Choroid	69	Enucleation	69	6	R	Exenteration	N	Y	30	24	71
F	Choroid	68	Exenteration + RT	68	0	R	(Exenteration + RT)	U	U	24	24	70
F	Choroid	67	Enucleation + RT	67	1	L	Debulking	Y	N	26	25	69
M	Choroid	37	Refused therapy	41	49	R	Exenteration + RT	Y	Y	84	35	43
F	Choroid	72	Palliation	72	0	L	(Palliation)	N	Y	39	39	75
F	Choroid	53	Enucleation	54	11	R	Exenteration + RT	N	Y	53	42	57
F	Choroid	59	Exenteration	59	0	R	(Exenteration)	N	Y	56	56	63
M	Choroid	23	RT	44	262	L	Debulking + RT	Y	Y	322	60	49
M	Choroid	71	Enucleation	71	0	R	(Enucleation)	N	N	105	105	80
M	Choroid	63	Exenteration + RT	63	0	R	(Exenteration + RT)	N	N	134	134	74
M	Choroid	60	Enucleation	62	25	L	Exenteration	N	N	184	159	75
M	Choroid	5	Enucleation	39	416	R	Exenteration	N	N	814	398	72
F	Choroid	62	Exenteration + RT	62	0	R	(Exenteration + RT)	N	N	17	17	N/A
F	Choroid	41	Exenteration + RT	41	0	L	Exenteration + RT	N	Y	30	30	N/A
M	Choroid	41	Enucleation	60	239	R	Debulking + RT	N	N	412	173	N/A
F	Choroid	36	Enucleation	53	208	R	Excisional biopsy + RT	Y	N	398	190	N/A
M	Choroid	48	Enucleation	49	16	L	Exenteration	N	Y		Lost to follow-up	Died date unknown
F	Choroid	54	RT	58	56	L	Exenteration + RT	N	N		Lost to follow-up	Died date unknown
F	Conj	70	Exenteration	70	0	R	Exenteration	N	Y	2	2	70
F	Conj	82	Excisional biopsy	82	8	R	Exenteration	U	Y	46	38	71
M	Conj	55	Local resection	56	12	R	Excisional biopsy	Y	Y	208	196	73
F	Conj	87	Local resection + RT	97	120	L	Exenteration	N	N	124	4	N/A
M	Conj	69	Local resection + RT	75	80	R	Exenteration + chemotherapy	N	Y	87	7	N/A
M	Conj	65	Local resection	69	51	R	Excisional biopsy	N	N	70	29	N/A
F	Conj	48	Local resection	59	128	R	Exenteration	N	Y	164	36	N/A
F	Conj	65	Local resection + RT	65	11	L	Debulking	Y	Y	63	52	N/A
M	Conj	87	Exenteration	87	0	R	Exenteration	N	Y	59	59	N/A
F	Conj	60	Nil	61	6	L	Exenteration	N	N	246	240	N/A
M	Skin	36	Local resection	43	87	L	Debulking + chemotherapy	N	Y	89	2	43
F	Skin	44	Local resection	63	234	L	Excisional biopsy	N	Y	240	6	64
F	Skin	58	Palliation	58	0	R	Palliation	N	Y	8	8	58
M	Skin	86	Local resection	88	28	R	Palliation	Y	Y	36	8	88
F	Skin	51	Local resection	57	83	L	Incisional biopsy + chemotherapy	N	Y	96	13	59
M	Skin	31	Local resection	34	52	BOTH	Extensive resection	U	U	72	20	36
M	Skin	51	Local resection	60	121	R	Biopsy + chemotherapy	N	Y	142	21	62
F	Skin	32	Local resection	64	362	L	Exenteration	N	N	363	1	N/A
F	Skin	54	Local resection	60	79	L	Exenteration + RT	N	N	87	8	N/A
M	Skin	54	Local resection	71	205	L	Debulking		Y	295	90	N/A
F	Skin	65	Local resection	67	41	R	Debulking + RT	N	Y	191	150	N/A
M	Unknown	61	Palliation	61	0	R	Palliation	N	Y	4	4	61
F	Nasal	54	Local resection	67	161	L	Debulking	Y	Y	201	45	71
F	Nasal	57	Local resection	61	48	L	Debulking + RT	U	Y	101	53	64
F	Sinus	59	Local resection	59	1	L	Debulking + RT	N	N	100	99	N/A

RT, radiotherapy.

Gray shaded cases can be considered truly metastatic disease, whilst non-shaded cases are likely to represent local spread or local micrometastasis.