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. 2017 Jun 22;7:4108. doi: 10.1038/s41598-017-04333-0

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Hypoxia-regulated intron retention targets are involved in RNA post-transcriptional modification and cancer function. (a) Tree diagram showing functional distribution of chronic hypoxia-regulated genes with significantly upregulated intron retention events (FDR < 0.01 and |ΔSI| ≥ 15%) that are involved in RNA post-transcriptional modification processes. (b) Network of hypoxia-regulated genes with significantly up-regulated intron retention events involved in cancer function. The network was generated using IPA with the criteria that only experimentally observed, direct relationships in human were used. Numbers indicate the ΔSI for each gene. The types of relationships include expression (E), protein-protein interactions (PP), activation (A), transcription (T), protein-DNA interactions (PD) and modifications (M).