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. 2017 Jun 22;7:4086. doi: 10.1038/s41598-017-04315-2

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Early (E8.5) SOX2 expression maps to both the cochlea and vestibular ganglia whereas later (E12.5) SOX2 expression maps to the glia. (A) Schematic of the early (E8.5) SOX2 fate-mapping timeline. (B,B”) Representative sections showing E8.5 tdT fate-mapped SOX2 expression in the SG and VG (C,C”) at E14.5. Note that tdT reporting specifically labels the neuronal cell bodies in both ganglia. (D) Schematic of the later (E12.5) SOX2 fate-mapping timeline. (E,E”) Representative sections showing E12.5 fate-mapped SOX2 expression reported with tdT in both the SG and (F,F”) VG at E14.5. Note that tdT reporting does not overlap with the neuronal cell bodies, but instead appears adjacent to the TUJ1 neuronal marker. (G,H’) Representative image showing that E8.5 SOX2-reported progenitors contribute to neuronal cell bodies in both the SG and VG at E14.5, and does not overlap with the glia cell marker, SOX10. In contrast (I,J’) show representative images where E12.5 SOX2 fate-mapped progenitors contribute nearly exclusively to SOX10 labeled glial cells in both the SG and VG. Scale bar: 50 μm.