Table 2.
Transcription factors, which show significantly better (>5% AUC) binding site predictability using (a) DynaSeq than DNAshape features and (b) vice versa of (a).
| S. No. | TF ID | TF Name | AUC gain (%) | S. No. | TF ID | TF Name | AUC gain (%) |
|---|---|---|---|---|---|---|---|
| (a) | |||||||
| 1 | MA03841 | SNT2 | 10.0 | 47 | MA01931 | Lag1 | 5.8 |
| 2 | CN00091 | LM9 | 9.7 | 48 | PB00051 | Bbx1 | 5.7 |
| 3 | PB00801 | Tbp1 | 9.4 | 49 | PB01791 | Sp1002 | 5.7 |
| 4 | MA03511 | DOT6 | 9.3 | 50 | MA02591 | HIF1AARNT | 5.6 |
| 5 | PL00131 | hlh2hlh15 | 8.6 | 51 | MA02671 | ACE2 | 5.6 |
| 6 | PH00341 | Gbx2 | 8.6 | 52 | CN00841 | LM84 | 5.6 |
| 7 | CN00441 | LM44 | 8.2 | 53 | MA03501 | TOD6 | 5.6 |
| 8 | PH01681 | Hnf1b | 8.2 | 54 | PB01261 | Gata52 | 5.6 |
| 9 | PH01641 | Six4 | 8.0 | 55 | PF00101 | GCCATNTTG | 5.6 |
| 10 | MA04001 | SUT2 | 7.7 | 56 | PB01321 | Hbp12 | 5.6 |
| 11 | PB01651 | Sox112 | 7.7 | 57 | PF00561 | GGGTGGRR | 5.6 |
| 12 | MA03351 | MET4 | 7.5 | 58 | MA02371 | pan | 5.5 |
| 13 | MA01382 | REST | 7.4 | 59 | MA01421 | Pou5f1 | 5.5 |
| 14 | MA01551 | INSM1 | 7.3 | 60 | POL0121 | TATABox | 5.5 |
| 15 | MA02251 | ftz | 7.1 | 61 | PB01111 | Bhlhb22 | 5.5 |
| 16 | MA00831 | SRF | 7.1 | 62 | MA02321 | lbl | 5.5 |
| 17 | CN00271 | LM27 | 7.0 | 63 | MA00411 | Foxd3 | 5.5 |
| 18 | MA01431 | Sox2 | 7.0 | 64 | PB01631 | Six62 | 5.4 |
| 19 | PH01071 | Msx2 | 7.0 | 65 | MA04071 | THI2 | 5.4 |
| 20 | MA00071 | Ar | 7.0 | 66 | PF01401 | RNGTGGGC | 5.4 |
| 21 | PB01981 | Zfp1282 | 6.9 | 67 | PB01751 | Sox42 | 5.4 |
| 22 | MA03861 | TBP | 6.9 | 68 | CN02111 | LM211 | 5.4 |
| 23 | PH01171 | Nkx31 | 6.8 | 69 | CN00521 | LM52 | 5.4 |
| 24 | PF00231 | TAATTA | 6.7 | 70 | PB01001 | Zfp7401 | 5.4 |
| 25 | PL00041 | hlh27 | 6.7 | 71 | MA02861 | CST6 | 5.4 |
| 26 | PB01571 | Rara2 | 6.7 | 72 | MA01851 | Deaf1 | 5.3 |
| 27 | PH01701 | Tgif2 | 6.6 | 73 | MA02701 | AFT2 | 5.3 |
| 28 | PH01161 | Nkx29 | 6.5 | 74 | PF00761 | CAGGTA | 5.3 |
| 29 | PL00181 | hlh25 | 6.4 | 75 | MA03141 | HAP3 | 5.3 |
| 30 | MA01031 | ZEB1 | 6.4 | 76 | PH01731 | Uncx | 5.2 |
| 31 | PH01481 | Pou3f3 | 6.3 | 77 | PF00121 | CAGGTG | 5.2 |
| 32 | MA00661 | PPARG | 6.2 | 78 | CN01571 | LM157 | 5.2 |
| 33 | CN02301 | LM230 | 6.2 | 79 | PF01421 | ACAWYAAAG | 5.2 |
| 34 | MA00181 | CREB1 | 6.2 | 80 | MF00031 | RELclass | 5.2 |
| 35 | PF01131 | AACYN NNNTTCCS | 6.2 | 81 | PH00981 | Lhx8 | 5.2 |
| 36 | MA00601 | NFYA | 6.1 | 82 | PF00131 | CTTTGT | 5.2 |
| 37 | PB01491 | Myb2 | 6.1 | 83 | PH00971 | Lhx62 | 5.2 |
| 38 | PH01221 | Obox2 | 6.0 | 84 | PB01501 | Mybl12 | 5.2 |
| 39 | PH01621 | Six2 | 6.0 | 85 | PH01091 | Nkx11 | 5.2 |
| 40 | CN00821 | LM82 | 6.0 | 86 | PB00081 | E2F21 | 5.2 |
| 41 | MA01591 | RXRRARDR5 | 6.0 | 87 | CN00591 | LM59 | 5.1 |
| 42 | PH00701 | Hoxc5 | 5.9 | 88 | MA02581 | ESR2 | 5.1 |
| 43 | CN01191 | LM119 | 5.9 | 89 | CN02101 | LM210 | 5.1 |
| 44 | MA04111 | UPC2 | 5.9 | 90 | MA01101 | ATHB5 | 5.0 |
| 45 | MA00861 | sna | 5.8 | 91 | MA00792 | SP1 | 5.0 |
| 46 | PF01631 | GGAR NTKYCCA | 5.8 | ||||
| (b) | |||||||
| S. No. | TF ID | TF Name | AUC gain (%) | ||||
| 1 | MF00071 | bHLHzipclass | 8.0 | ||||
| 2 | MA02771 | AZF1 | 7.0 | ||||
| 3 | PH00011 | Alx3 | 7.0 | ||||
| 4 | MA01951 | Lim3 | 6.5 | ||||
| 5 | PB01861 | Tcf32 | 6.2 | ||||
| 6 | PF01191 | GGGNRMNNYCAT | 5.7 | ||||
| 7 | MA01891 | E5 | 5.6 | ||||
| 8 | PH00111 | Alx12 | 5.5 | ||||
| 9 | CN00361 | LM36 | 5.4 | ||||
| 10 | MA01621 | Egr1 | 5.3 | ||||
| 11 | MA00131 | brZ4 | 5.3 | ||||
| 12 | PB01851 | Tcf12 | 5.2 | ||||