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. 2017 Jun 22;7:4035. doi: 10.1038/s41598-017-04406-0

Table 1.

Epigenetic drugs approved by FDA.

Drugs classification Approved Year Indicated disease ORR
Azacytidine 20 DNMT inhibitor 2004 MDS 17.9%
Vorinostat 32 HDAC inhibitor 2006 CTCL 30%
Decitabine 35 DNMT inhibitor 2006 MDS 42%~54%
Romidepesin 34 HDAC inhibitor 2009 TCL 34%
Ruxolitinib 36 JAK1/2 inhibitor 2011 Myelofibrosis 30%
Belinostat 33 HDAC inhibitor 2015 PTCL 25.8%
Panobinostat 25 HDAC inhibitor 2015 MM NA

MDS, Myelodysplastic syndrome; CTCL, Cutaneous T-cell lymphoma; TCL, T-cell lymphoma; PTCL, Peripheral T-cell lymphoma; MM, Multiple Myeloma, ORR, Objective response rate.